Journal of Applied Mathematics
Volume 2013 (2013), Article ID 715407, 11 pages
Research Article

Hemodynamic Features in Stenosed Coronary Arteries: CFD Analysis Based on Histological Images

1LUT School of Technology, Lappeenranta University of Technology, 53851 Lappeenranta, Finland
2Department of Cardiology, Emory University, Atlanta, GA 30322, USA
3Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
4Faculty of Medicine and Density, University of Bristol, Bristol BS8 1TH, UK

Received 8 March 2013; Revised 30 May 2013; Accepted 30 May 2013

Academic Editor: Chang-Hwan Im

Copyright © 2013 Mahsa Dabagh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Histological images from the longitudinal section of four diseased coronary arteries were used, for the first time, to study the pulsatile blood flow distribution within the lumen of the arteries by means of computational fluid dynamics (CFD). Results indicate a strong dependence of the hemodynamics on the morphology of atherosclerotic lesion. Distinctive flow patterns appear in different stenosed regions corresponding to the specific geometry of any artery. Results show that the stenosis affects the wall shear stress (WSS) locally along the diseased arterial wall as well as other adjacent walls. The maximum magnitude of WSS is observed in the throat of stenosis. Moreover, high oscillatory shear index (OSI) is observed along the stenosed wall and the high curvature regions. The present study is capable of providing information on the shear environment in the longitudinal section of the diseased coronary arteries, based on the models created from histological images. The computational method may be used as an effective way to predict plaque forming regions in healthy arterial walls.