Journal of Applied Mathematics
Volume 2013 (2013), Article ID 409387, 13 pages
Research Article

Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation

1Department of Mathematics, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
2Department of Materials Science and Engineering, Nanjing University, Nanjing 210093, China
3Department of Physics, Nanjing University, Nanjing 210093, China

Received 22 February 2013; Revised 11 May 2013; Accepted 27 May 2013

Academic Editor: Georgios Georgiou

Copyright © 2013 Tong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Erythrocyte aggregation and dissociation play an important role in the determination of hemodynamical properties of blood flow in microcirculation. This paper intends to investigate the adhesion and dissociation kinetics of erythrocytes through computational modeling. The technique of immersed boundary-fictitious domain method has been applied to the study of erythrocyte aggregates traversing modeled stenotic microchannels. The effects of stenosis geometry, cell membrane stiffness, and intercellular interaction strength on aggregate hemodynamics including transit velocity are studied. It is found that the width of the stenosis throat and shape of stenosis have a significant influence on the dissociation of the aggregates. Moreover, horizontally orientated erythrocyte aggregates are observed to dissociate much easier than their vertical counterparts under the same simulation conditions. Results from this study contribute to the fundamental understanding and knowledge on the biophysical characteristics of erythrocyte aggregates in microscopic blood flow, which will provide pathological insights into some human diseases, such as malaria.