International Journal of Mathematics and Mathematical Sciences
Volume 2003 (2003), Issue 32, Pages 2011-2026
A semilinear transport equation with delays
1Mansfield College, Oxford OX1 3TF, UK
2Dipartimento di Matematica Pura ed Applicata, Universitá di Padova, Padova, Italy
3Department of Mathematics, Vanderbilt University, Nashville 37235, TN, USA
Received 26 November 2002
Copyright © 2003 Janet Dyson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
An analysis is provided for a model of the blood production system
based on a cell population structured by a continuous variable corresponding to the maturity of individual cells. Cell maturity is viewed as an indicator of increasing
morphological development, ranging from the most primitive stem cells to the most mature differentiated cells. The analysis distinguishes two fundamental behaviors based on the nature of the initial state of the system: the first is a normal
production of cells, when the initial state contains a sufficient supply of the least mature cells; the second is an abnormal production, when the initial state is deficient in the population of the least mature cells.