Computational and Mathematical Methods in Medicine
Volume 2013 (2013), Article ID 567213, 11 pages
Research Article

Comparison of Simple Models of Periodic Protocols for Combined Anticancer Therapy

Department of Automatic Control, Silesian University of Technology, ul. Akademicka 2A, 44-100 Gliwice, Poland

Received 23 January 2013; Accepted 27 February 2013

Academic Editor: Enzo Grossi

Copyright © 2013 Marzena Dołbniak and Andrzej Świerniak. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Several simple ordinary differential equation (ODE) models of tumor growth taking into account the development of its vascular network are discussed. Different biological aspects are considered from the simplest model of Hahnfeldt et al. proposed in 1999 to a model which includes drug resistance of cancer cells to chemotherapy. Some of these models can be used in clinical oncology to optimize antiangiogenic and cytostatic drugs delivery so as to ensure maximum efficacy. Simple models of continuous and periodic protocols of combined therapy are implemented. Discussion on the dynamics of the models and their complexity is presented.