Computational and Mathematical Methods in Medicine
Volume 2012 (2012), Article ID 346713, 9 pages
Research Article

Influence of Expert-Dependent Variability over the Performance of Noninvasive Fibrosis Assessment in Patients with Chronic Hepatitis C by Means of Texture Analysis

1Computer Science Department, Faculty of Automation and Computer Science, Technical University of Cluj-Napoca, 28 Gheoghe Baritiu Street, 400027 Cluj-Napoca, Romania
2Regional Institute of Gastroenterology and Hepatology, Iuliu Hatieganu University of Medicine and Pharmacy, 19-21 Croitorilor Street, 400162 Cluj-Napoca, Romania

Received 1 August 2011; Accepted 26 September 2011

Academic Editor: Carlo Cattani

Copyright © 2012 Cristian Vicas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Texture analysis is viewed as a method to enhance the diagnosis power of classical B-mode ultrasound image. The present paper aims to evaluate and eliminate the dependence between the human expert and the performance of such a texture analysis system in predicting the cirrhosis in chronic hepatitis C patients. 125 consecutive chronic hepatitis C patients were included in this study. Ultrasound images were acquired from each patient and four human experts established regions of interest. Textural analysis tool was evaluated. The performance of this approach depends highly on the human expert that establishes the regions of interest ( 𝑃 < 0 . 0 5 ). The novel algorithm that automatically establishes regions of interest can be compared with a trained radiologist. In classical form met in the literature, the noninvasive diagnosis through texture analysis has limited utility in clinical practice. The automatic ROI establishment tool is very useful in eliminating the expert-dependent variability.