Computational and Mathematical Methods in Medicine
Volume 2011 (2011), Article ID 830515, 17 pages
doi:10.1155/2011/830515
Research Article

Computational Modeling of Tumor Response to Vascular-Targeting Therapies—Part I: Validation

Department of Mathematics and Statistics, The College of New Jersey, 2000 Pennington Road, P.O. Box 7718, Ewing, NJ 08628-0718, USA

Received 17 August 2010; Accepted 13 January 2011

Academic Editor: Henggui Zhang

Copyright © 2011 Jana L. Gevertz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mathematical modeling techniques have been widely employed to understand how cancer grows, and, more recently, such approaches have been used to understand how cancer can be controlled. In this manuscript, a previously validated hybrid cellular automaton model of tumor growth in a vascularized environment is used to study the antitumor activity of several vascular-targeting compounds of known efficacy. In particular, this model is used to test the antitumor activity of a clinically used angiogenesis inhibitor (both in isolation, and with a cytotoxic chemotherapeutic) and a vascular disrupting agent currently undergoing clinical trial testing. I demonstrate that the mathematical model can make predictions in agreement with preclinical/clinical data and can also be used to gain more insight into these treatment protocols. The results presented herein suggest that vascular-targeting agents, as currently administered, cannot lead to cancer eradication, although a highly efficacious agent may lead to long-term cancer control.